Cisplatin ototoxisch
WebSerum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen Poynter, Michelle Roesler & Jeannette Sample ... We will measure the association between blood serum platinum levels and ototoxicity, while adjusting for age at treatment, time since diagnosis, tumor ... WebNational Center for Biotechnology Information
Cisplatin ototoxisch
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WebFeb 14, 2024 · The National Comprehensive Cancer Network (NCCN) has updated clinical practice guidelines for Adolescent and Young Adults (AYA) Oncology to include sodium thiosulfate injection (Pedmark) to aid in mitigating the risk of cisplatin-associated ototoxicity in pediatric patients with localized, non-metastatic solid malignancies. 1 WebSep 18, 2024 · NCBI Bookshelf
WebApr 3, 2024 · Overall, hearing impairment shows a 5-fold higher risk with cisplatin use. “Ototoxicity can manifest as tinnitus, hearing loss in the high-frequency range (4000 to … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …
WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebSep 15, 2024 · Ototoxicity-Ototoxicity has been observed in up to 31% of patients treated with a single dose of cisplatin (cisplatin injection) 50 mg/m 2, and is manifested by …
WebSep 21, 2024 · Cisplatin and other platinum compounds are essential chemotherapeutic agents for the treatment of many pediatric malignancies. Unfortunately, platinum-based therapies can cause ototoxicity, or... cabinet choukrounWebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk of failing a grade in school. The consequences can be even more serious for very young children, added Dr. Cunningham. clown girl attorneyWebChemotherapeutic (antineoplastic) drugs, particularly those containing platinum ( cisplatin and carboplatin ), can cause tinnitus and hearing loss. Hearing loss can be profound and permanent, occurring immediately after the first dose, or can be delayed until several months after completion of treatment. clown ghoulWebJun 21, 2024 · This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival. Methods: cabinet chrysalideWebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, tachycardia, and hypotension. Hypersensitivity reactions have occurred within minutes of administration to patients with prior exposure toCisplatin for injection. clown girl animationWebOtotoxicity was more severe with higher cumulative doses and higher individual doses, and was most marked in those patients receiving bolus injections. Loss of perception of higher frequencies was most common. Symptoms of ototoxicity occurred in 23 patients and included deafness, tinnitus, otalgia, and recruitment. cabinet chrome handlesWebObjectives: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined. Materials and methods: In this prospective, observational cohort study, 206 adult HNSCC patients underwent … cabinet chrome