Cisplatin pharmacology
WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of … WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and …
Cisplatin pharmacology
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WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebAug 19, 2024 · Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its use and the dosage range applied have been limited by severe side effects (e.g., nephrotoxicity and ototoxicity) and by t …
WebTherefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in the present study, and we found that cisplatin increased the expression level of YAP1 in the mouse liver with H22 cells. Meanwhile, cisplatin improved the expression level of PD-L1, IL-1β and CCL2 in the tumor microenvironment. WebJun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. Platinol. Generic Name. Cisplatin. DrugBank Accession Number. DB00515. Background. Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based …
WebI am a PhD student in the Department of Pharmacology and Experimental Therapeutics at Boston University Division of Graduate Medical Sciences. ... They also offer hope that cisplatin and ... WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury.
WebOct 5, 2014 · Cisplatin is clinically proven to combat different types of cancers including sarcomas, cancers of soft tissue, bones, muscles, and blood vessels. …
WebOvarian cancer is an aggressive disease that affects about 300,000 patients worldwide, with a yearly death count of about 185,000. Following surgery, treatment involves adjuvant or neoadjuvant administration of taxane with platinum compounds cisplatin or carboplatin, which alkylate DNA through the same chemical intermediates. how do ace inhibitors treat heart failureWebCisplatin / pharmacology* Cisplatin / therapeutic use DNA / drug effects Drug Resistance / genetics Gene Expression Regulation, Neoplastic / drug effects Humans Organoplatinum Compounds / pharmacology ... how do achilles tears happenWebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, … how do ach withdrawals workWebCisplatin Injection is indicated as a single agent for patients with transitional cell bladder cancer which is no longer amenable to local treatments, such as surgery and/or … how do ach transfers workWebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel … how do ach payment workWebCisplatin Pharmacology Cisplatin About Cisplatin Alkylating Agent, Platinum- Analog , Antineoplastic. Mechanism of Action of Cisplatin Cisplatin exerts its cytotoxic effect by … how do acetylcholinesterase inhibitors workWebMar 28, 2024 · Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, … how do acids and bases affect our daily lives