2024 Ddb1- and cul4-associated factor 5

Ddb1- and cul4-associated factor 5

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August undefined, 2024

WebApr 12, 2024 · The damaged DNA-binding protein 1 (DDB1) enhances the survival and maintenance of multipotent cells through promoting the Cullin 4 E3 ligase complex-dependent ubiquitination and subsequent degradation of downstream substrates. Naive T cells could be activated and differentiated into effector and memory T cells by exogenous … WebApr 5, 2024 · DTL是CUL4-DDB1相关因子（DDB1 and CUL4 associated factor，DCAF）之一，可能参与恶性肿瘤的发展过程[2]。Cullin-RING E3泛素连接酶（Cullin-RING E3 ligase，CRL）拥有庞大的家族，参与基因转录、细胞周期调控、细胞分化、增殖、凋亡和肿瘤发生等过程[3]。DTL作为连接酶中的底物 ...

The CUL4-DDB1 ubiquitin ligase complex controls adult and

WebMay 18, 2012 · 612515 - DDB1- AND CUL4-ASSOCIATED FACTOR 17; DCAF17 - CHROMOSOME 2 OPEN READING FRAME 37; C2ORF37 - DCAF17 Toggle navigation ... The authors stated that in the alpha-isoform, the 1-bp deletion was predicted to lie in the 5-prime UTR and was unlikely to be pathogenic. The mutation was subsequently identified … WebThe human DDB1-CUL4 ASSOCIATED FACTOR (DCAF) proteins have been reported to interact directly with UV-DAMAGED DNA BINDING PROTEIN1 (DDB1) through the WDxR motif in their WD40 domain and function as substrate-recognition receptors for CULLIN4-based E3 ubiquitin ligases. Here, we identified and charac … pink led headlights

Expression profiling of WD40 family genes including …

WebDec 8, 2024 · DDB1- and CUL4-associated factor 5, WD repeat domain 22, WD repeat-containing protein 22 GeneRIFs: Gene References Into Functions Knockdown of L3MBTL3 or DCAF5 is sufficient to restore the protein levels of SOX2 and rescue the defects of mouse embryonic stem cells caused by LSD1 or PHF20L1 deficiency. WebApr 14, 2024 · Cullin-RING E3 ubiquitin ligase (CRL)-4 is a member of the large CRL family in eukaryotes. It plays important roles in a wide range of cellular processes, organismal development, and physiological and pathological conditions. DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate … Web5.1.2 DDB1. DDB1 is a binding ... More than 20 partner proteins of DDB1, collectively called DDB1- and CUL4-associated factors ... Binding of CSB recruits E3 ubiquitin ligase CRL4CSA, consisting of DDB1, CUL4, RBX1, and CSA (red). Stalled RNAP is then able to backtrack with the help of remodeling and sliding of upstream nucleosomes, facilitated ... pink led interior car lights

DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase

WebJun 7, 2004 · Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex By similarity 2 publications pathway Protein modification; protein ubiquitination. Features Showing features for repeat. Expand table WebAug 31, 2024 · Background: The WD40-repeat containing proteins, including DDB1-CUL4-associated factors (DCAFs), are abundant and conserved proteins that play important roles in different cellular processes including spermatogenesis. DCAFs are subset of WD40 family proteins that contain WDxR motif and have been proposed to function as … pink led folding vanity mirrorWebMar 29, 2024 · DCAF5DDB1 and CUL4 associated factor 5 [ Homo sapiens(human) ] Gene ID: 8816, updated on 23-Sep-2024 Download Datasets Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA) In addition, your package will include a detailed data report in both TSV and JSONL formats. pink led christmas tree lights

"WebDCAF5 DDB1 and CUL4 associated factor 5 [ (human)] Gene ID: 8816, updated on 8-Dec-2024 Summary Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr … " - Ddb1- and cul4-associated factor 5

Ddb1- and cul4-associated factor 5

Expression profiling of WD40 family genes including DDB1- and CUL4 …

WebMar 21, 2024 · GeneCards Summary for DCAF13 Gene. DCAF13 (DDB1 And CUL4 Associated Factor 13) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Metabolism of proteins . Gene Ontology (GO) annotations related to this gene include RNA binding . WebFeb 15, 2005 · DDB1- and CUL4-associated factor 17. Gene. DCAF17. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 520. Protein existence. Evidence at protein level. Annotation score. 5/5. Entry. Feature viewer. Publications. External links. History. BLAST Align. Download. Add Add a publication …

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WebApr 12, 2024 · The damaged DNA-binding protein 1 (DDB1) enhances the survival and maintenance of multipotent cells through promoting the Cullin 4 E3 ligase complex-dependent ubiquitination and subsequent degradation of downstream substrates. Naive T cells could be activated and differentiated into effector and memory T cells by exogenous … WebJan 10, 2024 · DCAF8L2 (DDB1 And CUL4 Associated Factor 8 Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF8L1. Additional gene information for DCAF8L2 Gene HGNC (31811) NCBI Entrez Gene (347442) Ensembl (ENSG00000189186) UniProtKB/Swiss-Prot (P0C7V8) Open Targets Platform (ENSG00000189186) Alliance …

WebLooking for online definition of DDB1- and CUL4-associated factor 5 in the Medical Dictionary? DDB1- and CUL4-associated factor 5 explanation free. What is DDB1- and CUL4-associated factor 5? Meaning of DDB1- and CUL4-associated factor 5 medical term. What does DDB1- and CUL4-associated factor 5 mean? WebOct 4, 2024 · Among E3 ubiquitin ligases known to be involved in the ubiquitination of Nrf2, DDB1 and Cullin4 associated factor 11 (DCAF11) was down-regulated at both protein and mRNA levels in stable cells, indicating that the repression of DCAF11 by TFEB may be mainly involved in the stabilization of Nrf2. ... DDB1 and CUL4 associated factor 11, …

WebPharos : Target Details - DCAF5 Jump to section: close Descriptive Data Protein Summary Protein Classes IDG Development Level Summary Expression Data Protein Sequence and Structure Related Tools Behavioral Data Approved Drugs Active Ligands Protein-Protein Interactions Nearest Tclin Targets Pathways Predicted Viral Interactions Phenotypic Data WebApr 11, 2024 · The HIV-1 Vpr Binding Protein (VprBP), also known as DDB1 and CUL4 Associated Factor 1, is a nuclear-localized protein and was originally identified owing to its interaction with HIV-1 Vpr in the ...

WebMay 24, 2004 · DDB1- and CUL4-associated factor 5 Gene Dcaf5 Status UniProtKB reviewed (Swiss-Prot) Organism Mus musculus (Mouse) Amino acids 946 Protein existence Evidence at protein level Annotation score 3/5 Entry Feature viewer Publications External links History BLAST Download Add Add a publication Entry feedback Function

WebThe cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC-2 channels. The CRBN-targeting immunomodulatory drug lenalidomide and the cullin E3 ligase inhibitor MLN4924 promotes and attenuates, respectively, proteasomal … steelers losses this yearWebNov 2013 - Aug 20247 years 10 months. Denver, Colorado, United States. Research Project-1: -High-efficiency direct reprogramming from fibroblasts into cardiomyocytes. •Mammalian Cell Line Cell ... pink led keyboard and mouseWebDDB1 and CUL4 associated factor 17. Normal Function. The DCAF17 gene provides instructions for making a protein whose function is unknown. The gene is active (expressed) in several organs and tissues in the body, including the brain, skin, and liver. Within cells, the protein produced from this gene is found in the nucleolus, which is a small ... pink led house lightsWebThe cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC-2 channels. The CRBN-targeting immunomodulatory drug lenalidomide and the cullin E3 ligase inhibitor MLN4924 promotes and attenuates, respectively, proteasomal … pink led light backgroundWebMar 21, 2024 · DCAF4L2 (DDB1 And CUL4 Associated Factor 4 Like 2) is a Protein Coding gene. Diseases associated with DCAF4L2 include Robinow Syndrome, Autosomal Recessive 1. An important paralog of this gene is DCAF4. Additional gene information for DCAF4L2 Gene. HGNC (26657) NCBI Entrez Gene (138009) pink led light up shoesWebThe gene, DGKH, encodes a member of the diacylglycerol kinase enzyme family , while DCAF5 encodes DDB1 and CUL4-associated factor 5 , and LINC02261 is a non-protein-coding lncRNA. None of the genes are known susceptibility loci … pink led lights for plantsWebJun 22, 2007 · The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. pink led light youtube