WebIn contrast to their transfection activity in vitro, the linear H2K carrier of plasmids was signifiantly more effective in vivocompared to the branch H2K4b. Surprisingly, negatively charged polyplexes formed by the linear H2K peptide gave higher transfection in vivo than did those with a positive surface charge. WebIn contrast to their transfection activity in vitro, the linear H2K carrier of plasmids was signifiantly more effective in vivocompared to the branch H2K4b. Surprisingly, negatively charged polyplexes formed by the linear H2K peptide gave higher transfection in vivo than did those with a positive surface charge.
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