Hoat1
NettetAs a result, hOAT1-mediated transport activity was compromised. Our data suggest that the peptide corresponding to TMD 6 of hOAT1 is a potent inhibitor of hOAT1 oligomerization and that oligomerization of hOAT1 is critical for the expression of the transporter at the cell surface and consequently for the proper function of the transporter. Nettet2. nov. 2013 · PCS is a substrate for hOAT1 and hOAT3, and hOAT1 and hOAT3 appear to play a physiological role as a high-capacity PCS transporter. Since hOATs are expressed not only in the kidneys, but also in blood vessels and osteoblasts, etc., these findings are of great significance in terms of elucidating the renal clearance, tissue …
Hoat1
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http://bjbalb.com/html/Primary-Antibody/GH0818.html Nettet1. jun. 2024 · The Ubiquitination of hOAT1 then triggers an accelerated endocytosis of the transporter from plasma membrane, which results in a reduced hOAT1 expression at the cell surface and a decreased hOAT1 ...
Nettetfor 1 dag siden · Wednesday. 29-Mar-2024. 07:06AM PDT Los Angeles Intl - LAX. 10:33AM HST Daniel K Inouye Intl - HNL. A332. 6h 27m. Join FlightAware View more … Nettet15. feb. 2024 · The concentration-dependent uptake of piperacillin by hOAT1/3-HEK293 cells was also investigated (Fig. 6 C and D). The K m and V max values of piperacillin uptake by hOAT1/3-HEK293 cells were 37 ± 5 μM and 0.173 ± 0.011 nmol/mg protein/min for hOAT1, and 172 ± 28 μM and 0.336 ± 0.022 nmol/mg protein/min for hOAT3 (Table 2).
NettetThe organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. [2] [3] [4] It is … Nettet28. aug. 2000 · Sequencing of several restriction subclones and of a PCR-generated clone revealed that the hOAT1 gene spans 8.2 kb and is composed of 10 exons divided by 9 introns. RT-PCR studies in a human kidney specimen led to the detection of two new splice variants, hOAT1-3 and hOAT1-4, showing a 132-bp in-frame deletion.
NettetOur previous study observed that chrysophanol and physcion were weak inhibitors of hOAT1 and hOAT3, with IC 50 values over 10 µM. 4) However, preincubation with 1 µM chrysophanol or physcion for 60 min resulted in 62 and 49% inhibition of hOAT1, respectively. In addition, preincubation with 5 µM chrysophanol or physcion for 60 min …
NettetWe previously showed that anthraquinones (including rhein, emodin, aloe-emodin, chrysophanol and physcion) were inhibitors of human organic anion transporter 1 (hOAT1) and hOAT3, causing transporter-mediated drug–drug interactions in rats. In this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was … townhomes lubbock for rentNettet1. jun. 2005 · In conclusion, stevioside had no interaction with either hOAT1 or hOAT3, whereas hOAT1, hOAT3, and fOat1 were all shown to be capable of steviol transport and thus, can play a role in its renal ... townhomes lubbockNettet18. aug. 1999 · cleotide analogs adefovir and cidofovir. To investigate the involvement of hOAT1 in the mechanism of nephrotoxicity associated with these two clinically important antiviral agents, Chinese hamster ovary (CHO) cells were stably transfected with hOAT1 cDNA. The resulting CHOhOAT cells showed probenecid-sensitive and pH-dependent … townhomes lubbock txNettet3. jan. 2024 · Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane … townhomes lubbock texasNettet19. jan. 2013 · Inhibitory effects of the nine test compounds on hOAT1-mediated PAH uptake. Ten-minute uptake of [3 H]PAH (1 μM) was measured in CHO-hOAT1 cells in the absence and presence of test compounds (50 μM) or probenecid (1000 μM).Data represent hOAT1-mediated transport specifically, that is, data have been corrected for … townhomes lowell maNettet24. mai 2005 · Since hOAT1 has been suggested as the basis of nephrotoxicity induced by nucleoside phosphonate analogs, this study raises the intriguing possibility that individuals with genetic variation in hOAT1, such as R50H, may display different handling of these drugs. Full text links . townhomes lumberton txtownhomes luxury