WebbKashin–Beck disease, a severe osteochondropathy seen mostly in China and related to ingestion of foods grown on selenium-deficient soil, results from combined dietary selenium and iodine deficiency, which can be alleviated by supplementation. Treatment with statins or aminoglycosides have also been reported to cause selenium deficiency. WebbThis study aims to uncover insight into the epigenetic modifications for Kashin-Beck disease (KBD) by integrating genome-wide association studies (GWAS), …
Genome-wide DNA methylation profiling of articular cartilage reveals ...
Webb1 juli 2016 · To understand how differentially methylated genes (DMGs) might affect the pathogenesis of Kashin-Beck disease (KBD). Genome-wide methylation profiling of … WebbKashin–Beck disease (KBD) is a degenerative osteoarticular disorder, and displays the significant differences with osteoarthritis (OA) regarding the etiology and molecular changes in... girls on point
MMP-10 Deficiency Effects Differentiation and Death of …
Webbmethylation profiles in the Cpg sites of DIO2, GPX3, and TXNRD1 promoter regions. these findings provide a strong background and new perspective for future studies on mechanisms underlying epigenetic regulation of selenoprotein genes associated with Oa and KBD diseases. Keywords osteoarthritis, Kashin-Beck disease, DNa methylation, … Webb9 okt. 2014 · Kashin‐Beck disease (KBD) is a chronic osteochondropathy, which is mainly characterized by cartilage degeneration, cartilage matrix degradation, chondrocyte necrosis, and apoptosis. KBD usually involves children ages 3–12 years, and the patients experience serious joint pain, joint deformities, and continually aggravated osteoarthritis … WebbSelenium deficiency is also associated with male infertility and might play a role in Kashin-Beck disease, a type of osteoarthritis that occurs in certain low-selenium areas of China, Tibet, and Siberia [1,2,5,6,8,22]. Selenium deficiency could exacerbate iodine deficiency, potentially increasing the risk of cretinism in infants [2,5]. girls onplatform shoes