Lamp2蛋白作用
Tīmeklis2024. gada 10. sept. · CD107a也被证明是淋巴细胞脱颗粒的标志物，如CD8+和NK细胞。. 细胞器标志物丨LAMP1抗体. Cat#：HPA014750. 规格：25ul/100ul. 应用类 … Tīmeklis大量证据表明自噬通路在多种疾病与生理过程中起着重要作用，如：神经系统疾病、肿瘤、心血管疾病、感染、代谢性疾病、自身免疫性疾病等等，自噬通路也就成为是很多疾病潜在的靶向治疗通路。. 大隅良典因“ …
Lamp2蛋白作用
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Tīmeklis摘要：. 溶酶体相关膜蛋白LAMP1 (lysosome-associated membrane protein 1)是主要存在于溶酶体膜上的一种高度糖基化的糖蛋白,参与细胞内多种生理和病理过程.近年有 … Tīmeklis2015. gada 10. dec. · The protein LAMP2 functions to protect lysosomal membranes from acid proteolysis. In this study, the authors show that malignant cells adapt to the acidic tumour microenvironment by redirecting ...
TīmeklisCells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). TīmeklisLamp-2：溶酶体膜蛋白，可用于监测自噬体与溶酶体融合。 LysoTrackerTM 探针：有红或蓝色可选，显示所有酸性液泡。 pDsRed2-mito：载体，转染后表达一个融合蛋白（红色荧光蛋白+线粒体基质定位信号），可用来检测线粒体被自噬掉的程度（Mitophagy）。 MitoTraker探针：特异性显示活的线粒体，荧光在经过固定后还能保留。 Hsp60：定 …
Tīmeklis2024. gada 28. marts · 总而言之，研究人员提出了LAMP2A在与ESCRT无关的过程中介导蛋白质包装到外泌体中，并且涉及HSC70对活性KFERQ序列的识别。 CD63 … Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysosome-associated membrane glycoprotein 2 Skatīt vairāk
TīmeklisLAMP2 has been suggested to play a role in protection of the lysosomal membrane from autodigestion, to maintain the acidic environment of the lysosome and to serve as an …
Tīmeklis2024. gada 27. jūl. · 在肿瘤转移过程中，LAMP1能作为microRNA抑制自噬并发挥抗肿瘤作用的直接靶点，其可通过引起溶酶体功能障碍并影响溶酶体水解酶的表达及活性发 … drs regulations scotlandTīmeklis产品详细信息. PA1-655 detects lysosome-associated membrane protein-2 (LAMP2) from rat, mouse and human tissues. PA1-655 has been successfully used in Western blot, immunofluorescence, and immunohistochemistry. By Western blot, this antibody detects glycosylated and non-glycosylated LAMP-2, depending on the lysis buffer used. color line handtücherTīmeklis2024. gada 11. janv. · Introduction. Danon disease (DD) is a rare monogenic lysosomal storage disorder that was first reported in 1981 (Danon et al., 1981).It is caused by loss-of-function mutations in the LAMP2 gene that encodes for lysosome-associated membrane protein-2, lower levels of which will lead to disrupted autophagy … drs reiter hill johnson \u0026 nevinTīmeklis2024. gada 18. marts · Lamp2 KO mice receiving AAV9.LAMP2B demonstrated dose-dependent restoration of human LAMP2B protein in the heart, liver, and skeletal muscle tissue. Impaired autophagic flux, evidenced by increased LC3-II, was abrogated by LAMP2B gene transfer in all tissues in both cohorts. drs reportingTīmeklis2024. gada 7. nov. · Lamp2 knockout (KO) mice are characterized by disrupted autophagy and phagocytosis in hepatocytes, neurons, and leukocytes (23–26). Loss-of-function mutations of the human LAMP2 gene cause Danon disease, a lysosomal storage disorder characterized by cardiomyopathy, skeletal myopathy, and mental … color line fra hirtshals til kristiansandTīmeklis2024. gada 15. okt. · LAMP2 is thought to protect the lysosomal membrane from proteolytic enzymes within lysosomes and to act as a receptor for proteins to be imported into lysosomes (Fukuda, 1994).Kain et al. (2008) found that virtually all individuals with pauci-immune focal necrotizing glomerulonephritis (FNGN) had … drs research supplementsTīmeklis2024. gada 8. janv. · Lysosome-associated membrane protein-2 (LAMP2), is a highly glycosylated lysosomal membrane protein involved in chaperone mediated autophagy. Mutations of LAMP2 cause the classic triad of myopathy, cardiomyopathy and encephalopathy of Danon disease (DD). Additionally, retinopathy has also been … drs replay