WebBackground: Cervical cancer, the third most prevalent cause of cancer in women worldwide, is associated with HPVs. The critical role of E7 protein in HPV-related malignancies has designated it as a strong contender for generating vaccines against HPV. Materials & methods: In this study, we developed a novel live vaccine using recombinant … WebJul 15, 2024 · Leishmania parasites are transmitted by the bite of phlebotomine sand flies and million cases of human infection occur annually. Leishmania tarentolae has been historically considered a non-pathogenic protozoan of reptiles, which has been studied mainly for its potential biotechnological applications.
Development of Various Leishmania ( Sauroleishmania) …
WebAug 12, 2024 · Leishmania tarentolae can survive in BALB/c mice, and its injection to mice effectively targets the dendritic cells and lymphoid organs, thereby increasing antigen presentation and the level and quality of T-cell immune responses. It has been applied as a vaccine against Leishmania donovani, inducing Th1, and increasing immunity in mice [ 19 ]. WebDec 13, 2024 · We suggest that the protozoan Leishmania tarentolae can be used as an easy-to-handle micro-factory for the rapid production of viral antigens to face emerging epidemics. We engineered L. tarentolae to express the SARS-CoV-2 Receptor Binding Domain (RBD) and report the ability of the purified RBD antigen to detect SARS-CoV-2 … maillard helicomatic tool
Leishmania tarentolae: Taxonomic classification and its …
WebLeishmania tarentolae Our LTE cell-free screening platform enables robust, time-efficient and highly reproducible analysis of protein–protein interactions in a multiplexed format. … WebThis study was undertaken to investigate the therapeutic effects of recombinant Leishmania tarentolae expressing CXCL-10 and an expression vector encoding CXCL-10 (pcDNA-CXCL-10-EGFP) in a model of BALB/c mice susceptible to infection by Leishmania major. The outcome of intervention was examined at 3 weeks post-treatment by evaluating the ... WebThe L. tarentolae α- and β-tubulin amino acid sequences are >98 and >96% identical to those found in pathogenic Leishmania species, respectively, and the susceptibility of L. … maillard freewheel removal