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Nejm hypothermia vs normothermia

WebOct 5, 2024 · In total, 930 patients were randomized to therapeutic hypothermia and 931 to normothermia. The hypothermia group had mortality of 50% while the normothermia group had mortality of 48% (relative risk [RR] 1.04, 95% confidence interval [CI] 0.94–1.14). The proportion of patients with mRS of 4 to 6 was 55% in both groups (RR 1.00, 95% CI … WebJul 3, 2024 · Reference: Dankiewicz et al: TTM2 Trial Investigators.Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. NEJM 2024. Population: Comatose adult patients admitted to hospital after an OHCA, irrespective of initial rhythm. Intervention: Hypothermia with a target temperature of 33 degrees Celsius, maintained for 28 hours, …

Hypothermia vs. Normothermia after OHCA Key Article Dankiewicz …

WebJan 29, 2024 · @article{Shrestha2024HypothermiaVN, title={Hypothermia versus normothermia after out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials}, author={Dhan Bahadur Shrestha and Yub Raj Sedhai and Pravash Budhathoki and Suman Gaire and Anurag Adhikari and Ayusha Poudel and … WebJul 22, 2024 · The authors of the TTM trial have now come out with their subsequent study looking to assess the benefit of avoiding fever versus targeting a specific temperature in critically ill patients following cardiac arrest. Paper: Dankiewicz J et al. Hypothermia Versus Normothermia After Out-Of-Hospital Cardiac Arrest. NEJM 2024. PMID: 34133859 raid 0 also known as https://cathleennaughtonassoc.com

Does hypothermia versus normothermia after out-of-hospital …

WebJun 17, 2024 · In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not lead to a lower incidence of death by 6 months than targeted normothermia. (Funded by the Swedish Research Council and others; TTM2 ClinicalTrials.gov number, NCT02908308.). WebJun 17, 2024 · At 6 months, 465 of 925 patients (50%) in the hypothermia group had died, as compared with 446 of 925 (48%) in the normothermia group (relative risk with hypothermia, 1.04; 95% confidence interval [CI], 0.94-1.14; p = 0.37). Of the 1,747 patients in whom the functional outcome was assessed, 488 of 881 (55%) in the hypothermia … WebNov 9, 2024 · TTM at 33°C vs. normothermia 37.5°C : Survival with a CPC of 1 or 2 at 90 days: Significantly improved survival with a CPC of 1 or 2 in hypothermia group but no difference in overall mortality: Dankiewicz et al. [TTM2 trial] 1861: RCT: 2024: OHCA with a presumed cardiac cause: TTM at 33°C vs. targeted normothermia 37.5°C : Death from … raiculopathy \\u0026pain in neck

Hypothermia versus Normothermia after Out-of-Hospital Cardiac …

Category:The New England Journal of Medicine

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Nejm hypothermia vs normothermia

A Contemporary Update on Targeted Temperature Management

WebDankiewicz J, et al. Hypothermia versus normothermia after out—of-hospital cardiac arrest. N Engl J Med. 2024; 384:2283-94. ... • The evidence for this recommendation began with 2 trials published in NEJM in 2002 that demonstrated improved neurologic outcome if OHCA patients who had a shockable rhythm and WebApr 13, 2024 · IntroductionLocal therapeutic hypothermia (32°C) has been linked experimentally to an otoprotective effect in the electrode insertion trauma. The pathomechanism of the electrode insertion trauma is connected to the activation of apoptosis and necrosis pathways, pro-inflammatory and fibrotic mechanisms. In a whole …

Nejm hypothermia vs normothermia

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WebThere were 23 deaths (21%) in the hypothermia group, as compared with 14 deaths (12%) in the normothermia group (relative risk of death with hypothermia therapy, 1.40; 95% CI, 0.90 to 2.27; P=0.06 ... WebThe New England Journal of Medicine

WebVISUAL ABSTRACT Hypothermia vs. Normothermia after Out-of-Hospital Cardiac Arrest. International guidelines recommend targeted temperature management to prevent hypoxic–ischemic brain damage in ... Mortality at six months was 41 percent in the hypothermia group (56 of 137 … Therapeutic hypothermia (also called targeted temperature management) is …

WebApr 12, 2024 · 5.1 Early Studies of Hypothermia in TBI. Early studies suggested improved outcomes with the use of induced hypothermia in severe TBI. Marion et al. (1997), in a randomized controlled trial (RCT), compared moderate hypothermia with normothermia in 82 patients with severe TBI, defined as GCS of 3–7 [].The patients randomized to … WebAug 6, 2024 · Dankiewicz J, et al. "Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest". The New England Journal of Medicine. 2024. 384(24):2283-2294. PubMed • Full text • PDF • ClinicalTrials.gov. Contents. 1 Clinical Question; 2 Bottom Line; 3 Major Points; 4 Guidelines; 5 Design;

WebJun 16, 2024 · However, while the target temperature for TTM could be 33ºC, 36ºC, or ≤37.5ºC, the relatively high survival rate found in the study (all cause mortality was 50% and 48% at 6 months in the hypothermia and normothermia groups, respectively) reinforces the need to ensure that each element of the TTM protocol is followed.

WebJun 15, 2024 · RESULTS The primary analyses included 2800 patients, with 1403 assigned to hypothermia and 1397 to normothermia. Death occurred for 691 of 1398 participants (49.4%) in the hypothermia group and 666 of 1391 participants (47.9%) in the normothermia group (rela-tive risk with hypothermia, 1.03; 95% con fidence interval … raid 0 for ssdWebNov 3, 2024 · NEJM, 2001. MRCT. normothermia vs moderate hypothermia (T33 C for 48 hours) improved ICP but no reduction in mortality. patients > 45 years do worse with induced hypothermia. if a patient arrives hypothermic -> do not warm to 37 (poorer outcome) if a patient arrives hypothermic -> they will have a significantly worse TBI. raicst meaningWebMar 28, 2024 · The Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital (THAPCA-OH) trial (ClinicalTrials.gov number, NCT00878644) compared therapeutic hypothermia (33°C) with therapeutic normothermia (36.8°C) in 295 children suffering from out-of-hospital cardiac arrest. raid 0 co to