Parafibromin
WebHome > Stains & CD markers > Parafibromin (CDC73) Parathyroid gland General parafibromin (CDC73) Author: Nat Pernick, M.D. Last staff update: 4 July 2024. Page … WebHRPT2基因是一种抑癌基因，其编码的Parafibromin蛋白可与PAF1形成复合体，再通过蛋白-DNA相互作用调控基因转录和翻译，进而诱导细胞凋亡或抑制细胞增殖[3-5]。在人体多 …
Parafibromin
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WebOct 1, 2010 · Overall, parafibromin is a marker of value to the endocrine pathologist, but it cannot be recommended as a sole indicator of parathyroid carcinoma. Additional … WebHRPT2/ parafibromin was immunoprecipitated from HEK293T whole cell lysate (1 mg per IP reaction, 20% loaded) with ab70533 at 6 µg per reaction. Western blot was performed on the immunoprecipitate using ab70533 at …
WebApr 7, 2024 · Of the 34 carcinomas evaluated for parafibromin, 17 showed parafibromin loss (< 5% nuclei staining) and 17 (50%) were parafibromin positive (median 30%, range 10–80% positive nuclei). Loss of … WebParafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has been coupled to familial and sporadic forms of …
WebJul 8, 2014 · Parafibromin is the protein product of the Hyperparathyroidism 2 (HRPT2) gene, originally found to be mutated in the majority of sporadic parathyroid cancers [27–29]. Loss of parafibromin expression predicts (HRPT2) gene mutation and was proposed as a highly sensitive marker for parathyroid cancer [27, 29, 30]. Recent studies have not ... WebParafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the …
WebJul 26, 2024 · Neural stem cells (NSCs) divide asymmetrically to balance their self-renewal and differentiation, an imbalance in which can lead to NSC overgrowth and tumour formation. The functions of Parafibromin, a conserved tumour suppressor, in the nervous system are not established. Here, we demonstrate that Drosophila Parafibromin/Hyrax …
WebParafibromin, encoded by CDC73 gene, exhibits antiproliferative properties by acting as a part of Polymerase Associated Factor 1 complex [6,7], directly interacting with nuclear b-catenin and Gli ... thomson d12-05b5-06Web黄菊香，聂连涛，申继红，李中健. 自1958年瑞典外科医生Ake Senning植入世界上第1例全埋藏式心脏起搏器以来，人工心脏起搏即成为治疗心动过缓的惟一有效方法，使近千万严重性心动过缓患者的心脏跳动得以恢复。 ulh healthrosterWebParafibromin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and … thomson d535071WebThe concept of parafibromin deficiency has been expanded upon and term "parafibromin deficient parathyroid neoplasm" is applied to a parathyroid neoplasm showing complete … thomson d15-32WebApr 4, 2024 · Down-regulated parafibromin is positively linked to the pathogenesis of parathyroid, lung, breast, ovarian, gastric and colorectal cancers. Here, we found that wild-type (WT) parafibromin overexpression suppressed proliferation, tumor growth, induced cell cycle arrest and apoptosis in colorectal cancer cells (p<0.05), but it was the converse … ulh health allocateWebJun 1, 2007 · Parafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has been coupled to familial and sporadic forms of parathyroid malignancy. In this study, we have conducted immunohistochemistry on 33 parathyroid carcinomas (22 unequivocal and 11 equivocal) … ulh knowledge hubWebContact Us To Get Started! Work with us – your premier oncology partner – to optimize cancer care for patients. Learn More. 9490 NeoGenomics Way. Fort Myers, FL 33912. T: … thomson d63 series smart tv