Phospho-acss2
WebJan 21, 2024 · We interrogate whether ACSS2 can facilitate the local transfer of acetyl groups. Our results point to direct transfer of intact acetate that is mediated by ACSS2, underscoring a critical function of acetate transfer in using local and nuclear acetate pools for histone acetylation and rapid transcriptional activation. WebDeacetylates ACSS2 leading to its activation, and HMGCS1. Involved in liver and muscle metabolism. ... All lanes : Anti-SIRT1 (phospho T530) antibody [EPNCIR153] (ab156585) at 1/1000 dilution Lane 1 : 293T cell lysates Lane 2 : 293T cell lysates treated with Calyculin A Lysates/proteins at 10 µg per lane. Secondary
Phospho-acss2
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WebSep 15, 2024 · The invention relates to novel compositions, combinations and methods relating to compounds which inhibit EZH2 and their uses for treating and/or preventing tumors associated with methyltransferase EZH2. More specifically the invention relates to synergistic bi-therapy compositions for use in a method of treating and/or preventing … WebDownload scientific diagram Cdk5 and p35 are important for proliferation of human TT cells. A, lysates of TT cells were immunoblotted by specific antibodies of Cdk5 and p35 with variant loading ...
WebAnti-ACSS2 Antibody (A-9) is a mouse monoclonal IgG 1 κ ACSS2 antibody, cited in 5 publications, provided at 200 µg/ml raised against amino acids 1-160 mapping at the N-terminus of ACSS2 of human origin Anti-ACSS2 Antibody (A-9) is recommended for detection of ACSS2 of mouse, rat and human origin by WB, IP, IF and ELISA WebJan 12, 2015 · ACSS2 exhibits copy-number gain in human breast tumors, and ACSS2 expression correlates with disease progression. These results signify a critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights …
Webphospho-Acetyl Coenzyme A Carboxylase beta Ser22 antibody (PE) Size Price Qty. 100 μl. $443.80. Add to Cart. Availability. Request Lead Time; In stock and ready for quick dispatch; Usually dispatched within 2 to 3 weeks. Shipping Destination: WebOct 2, 2024 · Acetyl-CoA synthetase 2 (ACSS2) is a conserved nucleocytosolic enzyme that converts acetate to acetyl-CoA. Adult mice lacking ACSS2 appear phenotypically normal …
WebImportantly, we show that ACSS2 Ser-267 phosphorylation regulates its stability by reducing polyubiquitination and degradation. ACSS2 Ser-267 is critical for OGT-mediated GBM …
WebMay 31, 2024 · A decrease in ACSS2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of neuronal genes. In adult mice, attenuation of hippocampal ACSS2 expression ... rebath curbless showerWebMay 31, 2024 · ACSS2 seems to bind to the promoters of immediate early genes before memory consolidation, implying that acetate, rather than ACSS2, is the limiting factor for histone acetylation at these genes. university of michigan medical school alumniWebSep 18, 2024 · Acss2 Deletion Protects Against Lipid Deposition and Obesity. To gain insight into the normal physiological function of ACSS2, we compared Acss2 -null mice with … rebath countertopsWebSep 18, 2024 · Acetyl-CoA synthetase 2 (ACSS2) is a conserved nucleocytosolic enzyme that converts acetate to acetyl-CoA. Adult mice lacking ACSS2 appear phenotypically normal but exhibit reduced tumor burdens in mouse models of liver cancer. The normal physiological functions of this alternate pathway of acetyl-CoA synthesis remain unclear, … university of michigan medical school anatomyWebThis gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl - … university of michigan medical residencyWebACSS2 / ACAS2 is a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate ... university of michigan medical school prereqsWebDownload scientific diagram Targeting OGT or CDKs blocks GBM growth ex vivo a Representative images depicting tumor growth in organotypic brain slices derived from mice intracranially injected ... university of michigan medical school wiki