WebThe solvents used are polyethylene glycol 400 and propylene glycol. As a preservative, the injectable solution contains benzyl alcohol. Toxicity from propylene glycol has been reported in the case of a person receiving a continuous lorazepam infusion. WebThe patient was suspected of having propylene glycol toxicity secondary to prolonged infusion of high-dose lorazepam (approximately 10–20 mg/hour averaged over 8 days).

Lorazepam Description, Uses, & Side Effects Britannica

WebEthylene glycol is a potent cause of acute toxicity in humans. In contrast, propylene glycol is a “generally recognized as safe” additive for foods and medications. Most reported cases … WebOct 1, 2004 · The chemical stabilities of these two extemporaneously prepared lorazepam suspensions were comparable throughout the study. Both lorazepam suspensions were stable for 63 days when stored at 4°C ... omni southpark austin reviews

Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions

WebThere have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of Lorazepam injection at higher than recommended doses. Symptoms may be more likely to develop in patients with renal impairment. WebDec 8, 2007 · This case illustrates the development of lorazepam-induced toxicity caused by the ... Each 1 mL of the base solution dispensed contains 2 mg of lorazepam and 0.18 mL of polyethylene glycol 400 in PG with 2.0% benzyl alcohol as a preservative. 5,7 The amount of PG was 0.8 ... Propylene glycol toxicity related to high ... WebI am a 76 y.o. man, fit, active, healthy. I’m in the process of weaning off lorazepam after six years of taking low doses daily. It is no easy task to cut down and completely stop taking these benzodiazepines, but I am highly motivated, doing well, no longer taking daily, and expect success. omnispace lockheed martin