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Combining structure-based pharmacophore modeling, virtual …
WebFeb 27, 2024 · Based on this new whole-cell screening approach, we demonstrated the optimization of a weak hit compound (2) into a small molecule (3) with improved in vitro and whole-cell activities. ... Jörg Haupenthal, Francesco Fulco, Eleonora Diamanti, and Anna K. H. Hirsch. 2024. "An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF ... WebApr 26, 2024 · The fruit fly Drosophila provides an inexpensive, rapid, quantitative, whole animal screening platform that has the potential to complement computational approaches. We present a chemical genetics approach that efficiently combines Drosophila with structural prediction and virtual screening, creating a unique discovery platform. hudsonville hs football schedule 2021
A Zebrafish Compound Screen Reveals Modulation of Neutrophil …
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