WebApr 27, 2024 · A Truncation mutations of TOPBP1 impaired Chk1 activation in response … WebThe initiation of DNA replication is an intricate and ordered sequence of events, requiring specific proteins to function in a particular order. Subsequent DNA damage checkpoints ensure that DNA is replicating correctly and errors in either of these mechanisms can have a significant effect on cell viability or controlled proliferation.
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Web15 TopBP1 in DNA Damage Response Ewa Forma, Magdalena Brys and Wanda M. … WebI am delighted to be the lead author of the review article "Targeting DNA damage response pathways in cancer", written with my colleagues at … htc 10 evo headphones
Eukaryotic DNA replication - Wikipedia
WebAug 31, 2024 · Mechanistically, CIP2A was discovered genome-widely the closest functional homologue for DNA-damage proteins TopBP1, RHNO, POLQ, NBN and PARP1. CIP2A directly interacts with the ATR-activation domain of TopBP1, and dampens both, chromatin binding of TopBP1 and RAD51, and G2/M checkpoint in DNA-damaged cells. WebJan 13, 2024 · Although aberrant mitosis and DNA damage generated at collapsed forks are the likely causes of cell ... required for checkpoint signaling like its orthologs TopBP1 in humans and Dpb11 in budding ... WebOct 8, 2024 · TOPBP1 and its fission and budding yeast orthologues Rad4 and Dpb11, respectively, are scaffold proteins that mediate formation of multi-protein complexes in a range of essential DNA replication and repair processes (Wardlaw et al., 2014).Homologues in vertebrates each contain nine BRCT domains, of which four (at the N-terminus; … htc 10 fingerprint scanner