WebMethyl triphenylmethyl ether. ≥97.0% (HPLC) View Price and Availability. Sigma-Aldrich. 471283. ... Protection/Deprotection Reagents. Description. ... Trityl chloride can be used as a catalyst: In Ritter type synthesis of 1-amidoalkyl-2-naphtols through a one-pot three-component reaction of naphthol, aryl aldehydes and acetonitrile. WebDde has been observed to undergo migration during piperidine mediated deprotection of N-ε-Fmoc-Lys and N-terminal Dpr residues, ... as the t-butyl ether. Trityl group removal is an equilibrium process, so must be performed using silanes to scavenge the trityl cations, or in a continuous flow mode to drive the equilibrium.
Chemoselective deprotection of trityl ethers using silica-supported …
WebSep 3, 2004 · Chemoselective hydrolysis of tert-butyl esters in the presence of other acid-labile groups has been explored by employing alpha-amino esters and ZnBr(2) in DCM. Although N-Boc and N-trityl groups were found to be labile, PhF protected amines were compatible with these Lewis acid deprotection conditi … http://ion.chem.usu.edu/~tchang/Chem7300/Carbohydrate/Chapter%203%20Protecting%20Groups.pdf mars international email
Efficient and catalytic deprotection of triphenylmethyl ethers with …
WebJan 1, 1978 · This report describes the use of 1-butanol-TFA for hydrolyzing trityl ethers under exceptionally mild conditions. In our initial studies to find a better procedure, the detritylation of 1 was accomplished with 90% (v/v) aqueous TFA for 2 min at room temperature to yield 2,3'-anhydro-l- (fi-D-xylofuranosyl)uracil7 as the sole u.v.-absorbing … WebTrityl Ethers-CPh3= Tr R-OH → R-OCPh3- selective for 1° alcohols - removed with mild acid; base stable formation: - Ph3C-Cl, pyridine, DMAP - Ph3C+BF4- Cleavage: - mild acid PROTECTING GROUPS 60 Methoxytrityl Ethers JACS1962, 84, 430 - methoxy group(s) make it easier to remove R2C O R R1 R3 WebA simple and efficient method has been developed for chemoselective deprotection of phenolic methoxymethyl (MOM) ethers at room temperature using silica-supported sodium hydrogen sulfate as a heterogeneous catalyst. C. Ramesh, N. Ravindranath, B. Das, J. Org. Chem., 2003 , 68, 7101-7103. mars interior